Recruiting and Retaining Breast Cancer Survivors into a Randomized Controlled Exercise Trial
Identifieur interne : 006961 ( Main/Exploration ); précédent : 006960; suivant : 006962Recruiting and Retaining Breast Cancer Survivors into a Randomized Controlled Exercise Trial
Auteurs : Melinda L. Irwin [États-Unis] ; Lisa Cadmus [États-Unis] ; Marty Alvarez-Reeves [États-Unis] ; Mary O Eil [États-Unis] ; Eileen Mierzejewski [États-Unis] ; Rebecca Latka [États-Unis] ; Herbert Yu [États-Unis] ; Loretta Dipietro [États-Unis] ; Beth Jones [États-Unis] ; M. Tish Knobf [États-Unis] ; Gina G. Chung [États-Unis] ; Susan T. Mayne [États-Unis]Source :
- Cancer [ 0008-543X ] ; 2008.
Abstract
Given observational findings that physical activity reduces breast cancer risk, improves survival, and improves quality of life in breast cancer survivors, a need has been identified for randomized controlled trials that testthe efficacy of exercise on biological mechanisms associated with breast cancer survival. The primary aims of the Yale Exercise and Survivorship Study were to 1) determine the feasibility of recruiting breast cancer survivors into a randomized controlled trial of the effects of exercise on biological markers and/or mechanisms associated with survival, 2) compare the effectiveness of various recruitment strategies on accrual rates and baseline characteristics, and 3) report adherence to the exercise trial.
Seventy-five postmenopausal breast cancer survivors self-referred into the trial or were recruited through the Connecticut Tumor Registry and randomly assigned to an exercise (n = 37) or usual-care (n = 38) group. The exercise group participated in 150 min/wk of supervised gym-based and home-based aerobic exercise for 6 months. The usual-care group was instructed to maintain current physical activity level.
A total of 75 women (an accrual rate of 9.5%) were randomized to the trial. Rates of accrual were higher for women who self-referred into the study (19.8%) compared with women recruited via the cancer registry (7.6%); however, demographic, physiologic, and prognostic characteristics did not differ between the 2 recruitment strategies. On average, exercisers increased moderate- intensity to vigorous-intensity aerobic exercise by 129 minutes per week compared with 44 minutes per week among usual-care participants (
Findings from this study will provide useful information for investigators who are conducting exercise trials in cancer populations, clinicians who are treating women diagnosed with breast cancer, and exercise professionals who are developing community-based exercise programs for cancer survivors.
Url:
DOI: 10.1002/cncr.23446
PubMed: 18428192
PubMed Central: 5450159
Affiliations:
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Irwin</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Cadmus, Lisa" sort="Cadmus, Lisa" uniqKey="Cadmus L" first="Lisa" last="Cadmus">Lisa Cadmus</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Alvarez Reeves, Marty" sort="Alvarez Reeves, Marty" uniqKey="Alvarez Reeves M" first="Marty" last="Alvarez-Reeves">Marty Alvarez-Reeves</name><affiliation wicri:level="2"><nlm:aff id="A2">Center for Community-based Research, Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Community-based Research, Dana Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="O Eil, Mary" sort="O Eil, Mary" uniqKey="O Eil M" first="Mary" last="O Eil">Mary O Eil</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Mierzejewski, Eileen" sort="Mierzejewski, Eileen" uniqKey="Mierzejewski E" first="Eileen" last="Mierzejewski">Eileen Mierzejewski</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Latka, Rebecca" sort="Latka, Rebecca" uniqKey="Latka R" first="Rebecca" last="Latka">Rebecca Latka</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Dipietro, Loretta" sort="Dipietro, Loretta" uniqKey="Dipietro L" first="Loretta" last="Dipietro">Loretta Dipietro</name><affiliation wicri:level="2"><nlm:aff id="A3">John B. 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Irwin</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Cadmus, Lisa" sort="Cadmus, Lisa" uniqKey="Cadmus L" first="Lisa" last="Cadmus">Lisa Cadmus</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Alvarez Reeves, Marty" sort="Alvarez Reeves, Marty" uniqKey="Alvarez Reeves M" first="Marty" last="Alvarez-Reeves">Marty Alvarez-Reeves</name><affiliation wicri:level="2"><nlm:aff id="A2">Center for Community-based Research, Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Community-based Research, Dana Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="O Eil, Mary" sort="O Eil, Mary" uniqKey="O Eil M" first="Mary" last="O Eil">Mary O Eil</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Mierzejewski, Eileen" sort="Mierzejewski, Eileen" uniqKey="Mierzejewski E" first="Eileen" last="Mierzejewski">Eileen Mierzejewski</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Latka, Rebecca" sort="Latka, Rebecca" uniqKey="Latka R" first="Rebecca" last="Latka">Rebecca Latka</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Dipietro, Loretta" sort="Dipietro, Loretta" uniqKey="Dipietro L" first="Loretta" last="Dipietro">Loretta Dipietro</name><affiliation wicri:level="2"><nlm:aff id="A3">John B. Pierce Laboratory, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>John B. Pierce Laboratory, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Jones, Beth" sort="Jones, Beth" uniqKey="Jones B" first="Beth" last="Jones">Beth Jones</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Knobf, M Tish" sort="Knobf, M Tish" uniqKey="Knobf M" first="M. Tish" last="Knobf">M. Tish Knobf</name><affiliation wicri:level="2"><nlm:aff id="A4">Yale School of Nursing, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale School of Nursing, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Chung, Gina G" sort="Chung, Gina G" uniqKey="Chung G" first="Gina G." last="Chung">Gina G. Chung</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Mayne, Susan T" sort="Mayne, Susan T" uniqKey="Mayne S" first="Susan T." last="Mayne">Susan T. Mayne</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Epidemiology and Public Health, Yale School of Medicine, New Haven</wicri:cityArea></affiliation></author></analytic><series><title level="j">Cancer</title><idno type="ISSN">0008-543X</idno><idno type="eISSN">1097-0142</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>BACKGROUND</title><p id="P1">Given observational findings that physical activity reduces breast cancer risk, improves survival, and improves quality of life in breast cancer survivors, a need has been identified for randomized controlled trials that testthe efficacy of exercise on biological mechanisms associated with breast cancer survival. The primary aims of the Yale Exercise and Survivorship Study were to 1) determine the feasibility of recruiting breast cancer survivors into a randomized controlled trial of the effects of exercise on biological markers and/or mechanisms associated with survival, 2) compare the effectiveness of various recruitment strategies on accrual rates and baseline characteristics, and 3) report adherence to the exercise trial.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">Seventy-five postmenopausal breast cancer survivors self-referred into the trial or were recruited through the Connecticut Tumor Registry and randomly assigned to an exercise (n = 37) or usual-care (n = 38) group. The exercise group participated in 150 min/wk of supervised gym-based and home-based aerobic exercise for 6 months. The usual-care group was instructed to maintain current physical activity level.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">A total of 75 women (an accrual rate of 9.5%) were randomized to the trial. Rates of accrual were higher for women who self-referred into the study (19.8%) compared with women recruited via the cancer registry (7.6%); however, demographic, physiologic, and prognostic characteristics did not differ between the 2 recruitment strategies. On average, exercisers increased moderate- intensity to vigorous-intensity aerobic exercise by 129 minutes per week compared with 44 minutes per week among usual-care participants (<italic>P</italic> < .001). Women in the exercise-intervention group increased their average pedometer steps by 1621 steps per day compared with a decrease of 60 steps per day among women in the usual-care group (<italic>P</italic> < .01).</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P4">Findings from this study will provide useful information for investigators who are conducting exercise trials in cancer populations, clinicians who are treating women diagnosed with breast cancer, and exercise professionals who are developing community-based exercise programs for cancer survivors.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Irwin, Melinda L" sort="Irwin, Melinda L" uniqKey="Irwin M" first="Melinda L." last="Irwin">Melinda L. Irwin</name></region><name sortKey="Alvarez Reeves, Marty" sort="Alvarez Reeves, Marty" uniqKey="Alvarez Reeves M" first="Marty" last="Alvarez-Reeves">Marty Alvarez-Reeves</name><name sortKey="Cadmus, Lisa" sort="Cadmus, Lisa" uniqKey="Cadmus L" first="Lisa" last="Cadmus">Lisa Cadmus</name><name sortKey="Chung, Gina G" sort="Chung, Gina G" uniqKey="Chung G" first="Gina G." last="Chung">Gina G. Chung</name><name sortKey="Dipietro, Loretta" sort="Dipietro, Loretta" uniqKey="Dipietro L" first="Loretta" last="Dipietro">Loretta Dipietro</name><name sortKey="Jones, Beth" sort="Jones, Beth" uniqKey="Jones B" first="Beth" last="Jones">Beth Jones</name><name sortKey="Knobf, M Tish" sort="Knobf, M Tish" uniqKey="Knobf M" first="M. Tish" last="Knobf">M. Tish Knobf</name><name sortKey="Latka, Rebecca" sort="Latka, Rebecca" uniqKey="Latka R" first="Rebecca" last="Latka">Rebecca Latka</name><name sortKey="Mayne, Susan T" sort="Mayne, Susan T" uniqKey="Mayne S" first="Susan T." last="Mayne">Susan T. Mayne</name><name sortKey="Mierzejewski, Eileen" sort="Mierzejewski, Eileen" uniqKey="Mierzejewski E" first="Eileen" last="Mierzejewski">Eileen Mierzejewski</name><name sortKey="O Eil, Mary" sort="O Eil, Mary" uniqKey="O Eil M" first="Mary" last="O Eil">Mary O Eil</name><name sortKey="Yu, Herbert" sort="Yu, Herbert" uniqKey="Yu H" first="Herbert" last="Yu">Herbert Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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